Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here,we defined themolecular...

Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment...

Highlights • MHC associated susceptibility represent the most prevalent genetic risk factors for the development of autoimmune diseases. This study uncovered a novel link between the MHC haplotype...

Allergic asthma is a chronical pulmonary disease with high prevalence. It manifests as a maladaptive immune response to common airborne allergens and is characterized by airway hyperresponsiveness,...

German-American research team has demonstrated a novel role of the complement system in brain aging process As people get older, structures and functions in the brain change. An important age-related...

The COVID-19 pandemic keeps the world in suspense uniting clinicians and basic researchers in their efforts to better understand disease pathogenesis and develop effective clinical interventions. The...

The European Union will fund the doctorate programme CORVOS for the next 4 years with 4.1 million Euros for by the Horizon 2020 programme. CORVOS stands for COmplement Regulation and Variations in...

In October 24-25th, 2019, the IRTG1911 had their yearly retreat at the Bretterbude in Heiligenhafen, Germany. After our arrival within the beautiful landscape directly at the beach, the following two...

Recent years have highlighted the close correlation between obesity and asthma. Most studies concluded that obesity is a risk factor for the development of asthma, increases asthma severity, and...

Complement plays critical roles in the innate defense against common pathogens. Our knowledge of the complement system has markedly expanded over the past few years. Novel findings in complement...