We have previously reported that increased expression and activation of kidney cell complement components play an important role in the pathogenesis of renal scarring. Here, we used floxed green...

Epidermolysis bullosa acquisita (EBA) is a rare blistering skin disease induced by autoantibodies directed against type VII collagen (COL7). Transfer of antibodies against murine COL7 (mCOL7) into...

Murine acetaminophen-induced acute liver injury (ALI) serves as paradigmatic model for drug-induced hepatic injury and regeneration. As major cause of ALI, acetaminophen overdosing is a persistent...

An der Universität zu Lübeck und dem UKSH Lübeck steht den Forschenden in der Cell Analysis Core Facility (CAnaCore) ab dem 01.02.2022 ein hochauflösendes „spektrales Durchflusszytometer“...

The complement system has evolved during the past 1.2 billion years, making it one of the oldest parts of the immune system. Since its discovery around 100 years ago, the system has been mainly...

Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified the complement anaphylatoxin C5a-mediated...

On April 29th, the Immunology Day is celebrated around the world. The motto in 2021 is COVID-19. The German Society for Immunology has compiled a lot of interesting material regarding the immune...

Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here,we defined themolecular...

Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment...

Highlights • MHC associated susceptibility represent the most prevalent genetic risk factors for the development of autoimmune diseases. This study uncovered a novel link between the MHC haplotype...