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Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation
Mariem Radhouani 1,2 , Asma Farhat 1,2 , Anna Hakobyan 2,3,4 , Sophie Zahalka 1,2 , Lisabeth Pimenov 1 , Alina Fokina 1 , Anastasiya Hladik 1 , Karin Lakovits 1 , Jessica Brösamlen 1 , Vojtech...
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Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoimmune blistering dermatosis
Björn Laffer 1, Mareike Ohms 1, Samyr Kenno 1, Ping Tsui 2, Elvira Ehlers-Jeske 1, Wenru Song 2, Wen-Chao Song 3 and Jörg Köhl 1 DOI: 10.3389/fimmu.2025.1560468 Introduction: Epidermolysis Bullosa...
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W2 (Associate) Professorship in AI-based predictive immune analytics
W2 Professorship in AI-BASED PREDICTIVE IMMUNEANALYTICS The ISEF is seeking a researcher to lead in applying AI/ML to complex immunological datasets for precision medicine. Shape innovative research,...
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Besetzung der W2- Professur Gewebsaskpekte von Immunität und Entzündung
Probevorträge – Programm Freitag, 22.11.2024, 08:30 Uhr  Ort: BMF Geb. 67, Marie-Curie-Strasse, Seminarraum 4. Etage 08.30-08.50 Uhr: Sabine Vettorrazzi - Ulm "Acting in synergy: Novel mechanisms...
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C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
Abstract Plexiform neurofibromas (PNFs) are nerve tumors caused by loss of NF1 and dysregulation of RAS-MAPK signaling in Schwann cells. Most PNFs shrink in response to MEK inhibition, but targets...
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Complement activation and cellular inflammation in Fabry disease patients despite enzyme replacement therapy
Björn Laffer, Malte Lenders, Elvira Ehlers-Jeske, Karin Heidenreich, Eva Brand, Jörg Köhl  PMID: 38304433 PMCID: PMC10830671 DOI: 10.3389/fimmu.2024.1307558 Abstract Defective a-galactosidase A...
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Microglia refine developing retinal astrocytic and vascular networks through the complement C3/C3aR axis
Gopalan Gnanaguru 1, Steven J Tabor 1, Gracia M Bonilla 2, Ruslan Sadreyev 2, 3, Kentaro Yuda 1, Jörg Köhl 4 5, Kip M Connor 1 Affiliations expand PMID: 36762625  PMCID: PMC10110418 (available on...
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C5aR1 activation in mice controls inflammatory eosinophil recruitment and functions in allergic asthma
Anna V Wiese 1, Jannis Duhn 1, Rabia Ülkü Korkmaz 1, Katharina M Quell 1, Ibrahim Osman 1, Fanny Ender 1, Torsten Schröder 1, 2, Ian Lewkowich 3, 4, Simon Hogan 5, Markus Huber-Lang 6, Franziska...
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B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy
Christopher C. Udoye1,6 , Christina N. Rau1,6 , Sarah M. Freye1 , Larissa N. Almeida1 , Sarah Vera-Cruz1 , Kai Othmer1 , Rabia Ü. Korkmaz1 , Ann-Katrin Clauder1 , Timo Lindemann1 , Markus Niebuhr2 ,...
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Anaphylatoxins spark the flame in early autoimmunity
The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate...
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