Abstract Plexiform neurofibromas (PNFs) are nerve tumors caused by loss of NF1 and dysregulation of RAS-MAPK signaling in Schwann cells. Most PNFs shrink in response to MEK inhibition, but targets...

Björn Laffer, Malte Lenders, Elvira Ehlers-Jeske, Karin Heidenreich, Eva Brand, Jörg Köhl  PMID: 38304433 PMCID: PMC10830671 DOI: 10.3389/fimmu.2024.1307558 Abstract Defective a-galactosidase A...

Gopalan Gnanaguru 1, Steven J Tabor 1, Gracia M Bonilla 2, Ruslan Sadreyev 2, 3, Kentaro Yuda 1, Jörg Köhl 4 5, Kip M Connor 1 Affiliations expand PMID: 36762625  PMCID: PMC10110418 (available on...

Anna V Wiese 1, Jannis Duhn 1, Rabia Ülkü Korkmaz 1, Katharina M Quell 1, Ibrahim Osman 1, Fanny Ender 1, Torsten Schröder 1, 2, Ian Lewkowich 3, 4, Simon Hogan 5, Markus Huber-Lang 6, Franziska...

Christopher C. Udoye1,6 , Christina N. Rau1,6 , Sarah M. Freye1 , Larissa N. Almeida1 , Sarah Vera-Cruz1 , Kai Othmer1 , Rabia Ü. Korkmaz1 , Ann-Katrin Clauder1 , Timo Lindemann1 , Markus Niebuhr2 ,...

The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate...

We have previously reported that increased expression and activation of kidney cell complement components play an important role in the pathogenesis of renal scarring. Here, we used floxed green...

Epidermolysis bullosa acquisita (EBA) is a rare blistering skin disease induced by autoantibodies directed against type VII collagen (COL7). Transfer of antibodies against murine COL7 (mCOL7) into...

Murine acetaminophen-induced acute liver injury (ALI) serves as paradigmatic model for drug-induced hepatic injury and regeneration. As major cause of ALI, acetaminophen overdosing is a persistent...

An der Universität zu Lübeck und dem UKSH Lübeck steht den Forschenden in der Cell Analysis Core Facility (CAnaCore) ab dem 01.02.2022 ein hochauflösendes „spektrales Durchflusszytometer“...