Im neuen Graduiertenkolleg GRK3095 wird erforscht, welche Mechanismen dazu führen, dass Antikörper entweder schützende oder krankmachende Reaktionen an Haut, Lunge und Darm auslösen. Die...

Mariem Radhouani 1,2 , Asma Farhat 1,2 , Anna Hakobyan 2,3,4 , Sophie Zahalka 1,2 , Lisabeth Pimenov 1 , Alina Fokina 1 , Anastasiya Hladik 1 , Karin Lakovits 1 , Jessica Brösamlen 1 , Vojtech...

Björn Laffer 1, Mareike Ohms 1, Samyr Kenno 1, Ping Tsui 2, Elvira Ehlers-Jeske 1, Wenru Song 2, Wen-Chao Song 3 and Jörg Köhl 1 DOI: 10.3389/fimmu.2025.1560468 Introduction: Epidermolysis Bullosa...

Abstract Plexiform neurofibromas (PNFs) are nerve tumors caused by loss of NF1 and dysregulation of RAS-MAPK signaling in Schwann cells. Most PNFs shrink in response to MEK inhibition, but targets...

Björn Laffer, Malte Lenders, Elvira Ehlers-Jeske, Karin Heidenreich, Eva Brand, Jörg Köhl  PMID: 38304433 PMCID: PMC10830671 DOI: 10.3389/fimmu.2024.1307558 Abstract Defective a-galactosidase A...

Gopalan Gnanaguru 1, Steven J Tabor 1, Gracia M Bonilla 2, Ruslan Sadreyev 2, 3, Kentaro Yuda 1, Jörg Köhl 4 5, Kip M Connor 1 Affiliations expand PMID: 36762625  PMCID: PMC10110418 (available on...

Anna V Wiese 1, Jannis Duhn 1, Rabia Ülkü Korkmaz 1, Katharina M Quell 1, Ibrahim Osman 1, Fanny Ender 1, Torsten Schröder 1, 2, Ian Lewkowich 3, 4, Simon Hogan 5, Markus Huber-Lang 6, Franziska...

Christopher C. Udoye1,6 , Christina N. Rau1,6 , Sarah M. Freye1 , Larissa N. Almeida1 , Sarah Vera-Cruz1 , Kai Othmer1 , Rabia Ü. Korkmaz1 , Ann-Katrin Clauder1 , Timo Lindemann1 , Markus Niebuhr2 ,...

The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate...

We have previously reported that increased expression and activation of kidney cell complement components play an important role in the pathogenesis of renal scarring. Here, we used floxed green...