Welcome to the ISEF

The Institute for Systemic Inflammation Research (ISEF) was founded in 2008 as a research institute within the medical section of the University of Lübeck (UzL). The ISEF is dedicated to delineate the cellular and molecular mechanisms underlying dysregulated innate and adaptive immune responses in allergic, autoimmune and infectious diseases. For this purpose, we use in vitro and in vivo experimental disease models. Ultimately, we strive to translate such knowledge and advances into new diagnostic, preventive and therapeutic approaches.

Our vision –

for a better understanding of immunology

Research

Here, you will find more information about the ongoing research at the ISEF and the individual working groups.

News

Here, you find latest news of the institute, including recently published research articles, events and updates.

Staff

Here, you find more information on the members of the ISEF

News

Cell type–specific purifying selection of synonymous mitochondrial DNA variation

PMID: 40705423 PMCID: PMC12318227 DOI: 10.1073/pnas.2505704122 Autoren: Caleb A. Lareau a,b,1,2, Patrick Maschmeyer c,d,1, Yajie Yin b, Jacob C. Gutierrez a,b, Ryan S. Dhindsa e,f,g, Anne-Sophie...

Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy

Identifier: PMID: 41167637 PMCID: PMC12574404 DOI: 10.1136/jitc-2025-012350 Authors: Ambre Manon Giguelay1,2,*, Patrick Maschmeyer1,2,3,*, Leonie Müller- Jensen1,4, Christian Schinke1,4, Smilla K...

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