Welcome to the ISEF

The Institute for Systemic Inflammation Research (ISEF) was founded in 2008 as a research institute within the medical section of the University of Lübeck (UzL). The ISEF is dedicated to delineate the cellular and molecular mechanisms underlying dysregulated innate and adaptive immune responses in allergic, autoimmune and infectious diseases. For this purpose, we use in vitro and in vivo experimental disease models. Ultimately, we strive to translate such knowledge and advances into new diagnostic, preventive and therapeutic approaches.

Our vision –

for a better understanding of immunology

Research

Here, you will find more information about the ongoing research at the ISEF and the individual working groups.

News

Here, you find latest news of the institute, including recently published research articles, events and updates.

Staff

Here, you find more information on the members of the ISEF

News

Microglia refine developing retinal astrocytic and vascular networks through the complement C3/C3aR axis

Gopalan Gnanaguru 1, Steven J Tabor 1, Gracia M Bonilla 2, Ruslan Sadreyev 2, 3, Kentaro Yuda 1, Jörg Köhl 4 5, Kip M Connor 1 Affiliations expand PMID: 36762625 PMCID: PMC10110418 (available on...

C5aR1 activation in mice controls inflammatory eosinophil recruitment and functions in allergic asthma

Anna V Wiese 1, Jannis Duhn 1, Rabia Ülkü Korkmaz 1, Katharina M Quell 1, Ibrahim Osman 1, Fanny Ender 1, Torsten Schröder 1, 2, Ian Lewkowich 3, 4, Simon Hogan 5, Markus Huber-Lang 6, Franziska...

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