Welcome to the ISEF

The Institute for Systemic Inflammation Research (ISEF) was founded in 2008 as a research institute within the medical section of the University of Lübeck (UzL). The ISEF is dedicated to delineate the cellular and molecular mechanisms underlying dysregulated innate and adaptive immune responses in allergic, autoimmune and infectious diseases. For this purpose, we use in vitro and in vivo experimental disease models. Ultimately, we strive to translate such knowledge and advances into new diagnostic, preventive and therapeutic approaches.

Our vision –
for a better understanding of immunology


Christopher C. Udoye1,6 , Christina N. Rau1,6 , Sarah M. Freye1 , Larissa N. Almeida1 , Sarah Vera-Cruz1 , Kai Othmer1 , Rabia Ü. Korkmaz1 , Ann-Katrin Clauder1 , Timo Lindemann1 , Markus Niebuhr2 ,...
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The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate...
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