Welcome to the ISEF

The Institute for Systemic Inflammation Research (ISEF) was founded in 2008 as a research institute within the medical section of the University of Lübeck (UzL). The ISEF is dedicated to delineate the cellular and molecular mechanisms underlying dysregulated innate and adaptive immune responses in allergic, autoimmune and infectious diseases. For this purpose, we use in vitro and in vivo experimental disease models. Ultimately, we strive to translate such knowledge and advances into new diagnostic, preventive and therapeutic approaches.

Our vision –

for a better understanding of immunology

Research

Here, you will find more information about the ongoing research at the ISEF and the individual working groups.

News

Here, you find latest news of the institute, including recently published research articles, events and updates.

Staff

Here, you find more information on the members of the ISEF

News

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation

Mariem Radhouani 1,2 , Asma Farhat 1,2 , Anna Hakobyan 2,3,4 , Sophie Zahalka 1,2 , Lisabeth Pimenov 1 , Alina Fokina 1 , Anastasiya Hladik 1 , Karin Lakovits 1 , Jessica Brösamlen 1 , Vojtech...

Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoimmune blistering dermatosis

Björn Laffer 1, Mareike Ohms 1, Samyr Kenno 1, Ping Tsui 2, Elvira Ehlers-Jeske 1, Wenru Song 2, Wen-Chao Song 3 and Jörg Köhl 1 DOI: 10.3389/fimmu.2025.1560468 Introduction: Epidermolysis Bullosa...

Provider	gradwerk
Purpose	Saves the user's consent status for cookies at the current domain address.
Expiry	1 year
Type	HTTP

Provider	Vimeo
Purpose	Saves the user's preferences when playing embedded videos from Vimeo. Enables the correct functionality of these videos.
Expiry	1 year
Type	HTTP

Provider	YouTube Google
Purpose	YouTube bandwidth measurement
Expiry	6 months
Type	HTTP

Provider	gradwerk
Purpose	Saves the user's access for recognition (unique visitor).
Expiry	3 years
Type	HTTP

Provider	gradwerk
Purpose	Saves the referrer, i.e. the transferring website from which the user comes and the first page (area, page and language ID, time).
Expiry	Session
Type	HTTP

Provider	Google
Purpose	Google uses cookies such as the NID to customise advertising in Google products such as Google Search. This cookie is used in Google Maps, for example.
Expiry	6 months
Type	HTTP