IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease

• MHC associated susceptibility represent the most prevalent genetic risk factors for the development of autoimmune diseases. This study uncovered a novel link between the MHC haplotype and IgG Fc N-glycosylation that controls the development of autoimmune skin disease
• IgG autoantibodies with an agalactosylated, proinflammatory N-glycan moieties induced strong ROS release by neutrophils, which are important mediators of autoimmune skin inflammation 
• Enhanced IgG-autoantibodies and disease development was associated with higher numbers of IL-21- and IFN-γ-producing autoantigen-specific CD4+ T cells and Tfh cells
• The results of the study suggest that analysis of IgG autoantibody glycosylation may help improving the predictive value of autoantibody diagnostics in autoimmune blistering skin diseases 

Clauder et al. JID 2020

PMID: 32653301 DOI: 10.1016/j.jid.2020.06.022